High Sierra Transport, price: $99.99 (20% off retail price) at eBags plus FREE shipping 3564 cu. in. 23" x 14.5" x 8.5", removable daypack 14" x 12" x 5.5", weighs 4 lbs , 8 oz. Large front load main compartment opens for easy packing. Removable shoulder strap with padded shoulder pad on the left side panel. NOTE: Cloth zipper pulls cannot be locked securely. Use luggage lock or cable lock on the metal bases of the zippers.
 

Rick Steves Convertible Carry-On, Price:$99.00 at Luggage Pros 2500 cu. in.21" x 14" x 9", weighs 3.5 lbs.Converts from suitcase to backpack with comfortable shoulder straps and padded waistbelt. Three exterior pockets. Includes two mesh bags and clip-in security pouch. Internal and external compression straps. Zipper expansion adds 500 cu.in.

 
Eagle Creek Meridian 55L Travel Pack, price: $110.95 (38% off retail) at Sierra Trading Post (additional 10% off for first time customers)3150 cu. in., 26.5" x 15" x 10", weighs 5 lbs, 5 oz., Large main compartment with easy access front panel loading.  External front compartment with locking zippers is perfect for a Pack it cube, 15" Folder or the Wallaby toiletry kit. Lower seam sealed wet/dry compartment to separate dirty from clean contents. Limited availability.

High Sierra Railpass, price: $119.99 (20% off retail price) at eBags plus FREE shipping 5015 cu. in. 26" x 15" x 9", removable daypack 14" x 12" x 5.5", weighs, 5 lbs, 8 oz. Large front load main compartment hinges open from the side for easy packing. Removable, adjustable aluminum stays can be bent to fit the contours of your back to customize fit and increase comfort. NOTE: Cloth zipper pulls cannot be locked securely. Use luggage lock or cable lock on the metal bases of the zippers.

High Sierra Compass, price: $129.99 (24% off retail price) at eBags plus FREE shipping  5408 cu. in., 29" x 15" x 10", daypack=860 cu. in. weighs 6 lbs, 8 oz. Two large main compartments; the back compartment hinges open fron the side for easy packing. Zippered divider panel between front and back compartments opens to make one large compartment. Removable, adjustable aluminum stays can be bent to fit the contours of your back to customize fit and increase comfort. NOTE: Cloth zipper pulls cannot be locked securely. Use luggage lock or cable lock on the metal bases of the zippers.

 
JanSport Deluxe Euro Sak, price $139.99 (43% off retail price) at eBags plus FREE shipping 3950 cu. in. (expands to 5450 cu. in), 35" x 16" x 11",  daypack= 750, weighs in 6 lbs, 5 oz. AirLift shoulder straps, padded hip belt and adjustable zip-awat stenum strap. PE frame sheet and aluminum stays. External compression for load control. Fully lined with PU-coated spill-resistant nylon.

Eagle Creek Centerline Meridian 55L, price: $180 at eBags plus FREE shipping 3150 cu. in., 26.5" x 15" x 10", weighs 5 lbs, 5 oz., Large main compartment with easy access front panel loading.  External front compartment with locking zippers is perfect for a Pack it cube, 15" Folder or the Wallaby toiletry kit. Lower seam sealed wet/dry compartment to separate dirty from clean contents.

Eagle Creek Centerline Voyage 65L, price: $185 at eBags plus FREE shipping 3800 cu. in., 23" x 14" x 9", weighs 4 lbs 6oz., removable daypack=1200 cu. in. Large main compartment with easy access front panel loading. Sternum strap, load lifter straps, and adjustable padded hip belt for a comfortable fit and carry.

Eagle Creek Explorer, price: $187.50 (25% off retail) at eBags plus FREE shipping 4200 cubic inches, 22" x 14" x 8.5",  weighs 4 lbs. 2 oz., internal frame, removable daypack=1200 cu. in.  3-In-1 Travel shell offers rain protection, check through security and acts as a stand alone duffel.  Offers quick top load access and a front panel load design for easy packing and unpacking. HDPE Frame Sheet and one curved stay to distribute load weight from back and shoulders.

Eagle Creek Ultimate Explorer LT, price: $206. 25 (25% off retail) at eBags plus FREE shipping 5400 cu. in., 29" x 15" x 9", weighs 7 lbs. Detachable daypack with zip away travel water bottle pockets and organizer panel. Offers quick top load access and a front panel load design for easy packing and unpacking. HDPE frame sheet and two curved stays to distribute load from back and shoulders.

 
Eagle Creek Centerline Maiden Voyage 70L, price: $225 at eBags plus FREE shipping 4350 cu. in., 26" x 14" x 10", daypack=1200 cu. in., weighs 6 lbs, 4 oz. Removable daypack. Designed specifically to fit women. Large main compartment with easy access front panel loading. Lower seam sealed wet/dry compartment to separate dirty clothes from the clean. HDPE frame sheet and a durable curved stay for a custom, contoured fit.

Eagle Creek Centerline Grand Voyage 90L, price: $225 at eBags plus FREE shipping 5600 cu. in., 29" x 15" x 12", weighs 6 lbs, 6 oz. removable daypack=1200 cu. in. Large main compartment with easy access front panel loading. Lower seam sealed wet/dry compartment to separate dirty from clean contents.

 
Osprey Men's Waypoint 60 Pack, price: $229 at Moosejaw plus FREE shipping Medium: Volume cu.in./liters: 3700/60. Weight: 3lbs13ozs/1.73 kgs. Large: Volume cu.in./liters: 3900/63. Waypoint Day Pack Volume cu.in./liters: 600/10 Weight: 1lbs2ozs/0.51kgs. Interchangeable IsoForm harnesses help you customize the fit while a built in ErgoPull hipbelt keeps the load comfortably on your hips without being bulky. A detachable daypack with plastic framesheet keeps your smaller items safe. Large panel zip to allow easy access to main compartment. Zip away straps.  
Osprey Women's Waypoint 60, price $229 at Moosejaw plus FREE shipping  Small: Volume cu.in./liters: 3500/57. Medium: Volume cu.in./liters: 3700/60. Weight: 4lbs4ozs/1.73 kgs. Waypoint Day Pack Volume cu.in./liters: 600/10 Weight: 1lbs2ozs/0.51kgs. Award-winning Ethereal suspension (same as Aether 60) with aluminum headrail for ample headspace Panel load access Detachable daypack Foam sidewalls Women's IsoForm harness and built-in ErgoPull hipbelt.

The North Face Backtrack 70, price: $288.95 at eBags plus FREE shipping  4250 cu. in., 28" x 15" x 7" , weighs 8 lbs. 8 oz. Removable day pack clips into place. Braided cable through top carry handle for lockable security. Zippered suspension cover doubles as a rain cover,  Sleeping bag compartment with wet / dry divider. Large main pocket with internal compression panel with zip mesh pocket.
 

Still don't see the right pack for you? Check out my places to buy backpacks to find the right pack at the right price.

Wheeled Bags:
I don't recommend wheeled packs, but if you feel compelled to buy one, then here are some of the packs available.

 
High Sierra Rolling Backpack 22", price: $69.95 (56% off retail) at Sierra Trading Post 2290 cu. in., 22" x13" x 8" (without daypack attached), weighs 7 lbs. 6 oz. Removable daypack. Removable padded shoulder strap. Main compartment with tie-down straps and compression straps. Limited availability.

 
A.T. Gear Access Carry-On Wheeled Backpack with Removable Daypack, price: $129.99 (24% off retail) at eBags plus FREE shipping 2300 cu. in., 20.5" x 14" x 8", weighs 9 lbs., Removable interior pack measuring 17"x13"x7". Inline skate-style wheels with corner protectors.Hidden padded backpack straps are stored behind the zippered padded back panel.

Eagle Creek Centerline Cross Roads Convertible 25, price: $230 at eBags plus FREE shipping 3750 cu. in., 25" x 25" x 10", 8 lbs, Main compartment expands 2.5" for an extra 25% capacity. Oversized off-road wheels provide a smooth, reliable ride over all terrains.

Victorinox Trek Pack Plus 3.0 24" Wheeled Backpack with Docking Daypack, price: $239. 99 (44% off retail) at eBags plus FREE shipping 4700 cu. in., 24" x 16" x 11.5", weighs 8 lbs. 13 oz. Removable pack measures 11”w x 17”h x 6” d – 790 cubic inches. Dual-access sleeping bag/boot compartment cinches closed to keep items separate from other contents. Removable leak proof pouch. Removable mesh pouch. Zip-away contoured flame-laminated, die-cut shoulder straps and hip belt.

Still don't see the right pack for you? Check out my places to buy backpacks to find the right pack at the right price. 

Prices listed above are in US$. Price and availability of packs is subject to change (please let me know if the prices have changed or the packs are no longer available and I will correct my listings ASAP).